The mechanism of amphetamine-induced inhibition of rat substantia nigra compacta neurones investigated with intracellular recording in vitro
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منابع مشابه
Distinct mechanisms of presynaptic inhibition at GABAergic synapses of the rat substantia nigra pars compacta.
We investigated the mechanisms of presynaptic inhibition of GABAergic neurotransmission by group III metabotropic glutamate receptors (mGluRs) and GABA(B) receptors, in dopamine (DA) neurons of the substantia nigra pars compacta (SNc). Both the group III mGluRs agonist L-(+)-2-amino-4-phosphonobutyric acid (AP4, 100 microM) and the GABA(B) receptor agonist baclofen (10 microM) reversibly depres...
متن کاملIntracellular sodium and calcium homeostasis during hypoxia in dopamine neurons of rat substantia nigra pars compacta.
We investigated the hypoxia-induced disturbance of cytosolic sodium concentration ([Na+]i) and of cytosolic calcium concentration ([Ca2+]i) in dopamine neurons of the substantia nigra pars compacta in rat midbrain slices, by combining whole cell patch-clamp recordings and microfluorometry. Transient hypoxia (3-5 min) induced an outward current (118.7 +/- 15.1 pA, mean +/- SE; VH = -60 mV). The ...
متن کاملSubthalamic stimulation-induced synaptic responses in substantia nigra pars compacta dopaminergic neurons in vitro.
The subthalamic nucleus (STN) is one of the principal sources of excitatory glutamatergic input to dopaminergic neurons of the substantia nigra, yet stimulation of the STN produces both excitatory and inhibitory effects on nigral dopaminergic neurons recorded extracellularly in vivo. The present experiments were designed to determine the sources of the excitatory and inhibitory effects. Synapti...
متن کاملAmphetamine-induced release of dopamine from the substantia nigra in vitro.
Incubation of chopped tissue from the substantia nigra of the rat brain with d-amphetamine resulted in a significant release of [3H]dopamine into the incubation medium. This effect was observed with both exogenous [3H]dopamine previously taken up by the tissue and [3H]dopamine endogenously synthesized from L-[3,5-3H]tyrosine. The observed release was greater in magnitude when the apparent conve...
متن کاملMg2+ block properties of triheteromeric GluN1–GluN2B–GluN2D NMDA receptors on neonatal rat substantia nigra pars compacta dopaminergic neurones
Native NMDA receptors (NMDARs) are tetrameric channels formed by two GluN1 and two GluN2 subunits. So far, seven NMDARs subunits have been identified and they can form diheteromeric or triheteromeric NMDARs (more than one type of GluN2 subunit). Extracellular Mg(2+) is an important regulator of NMDARs, and particularly the voltage dependence of Mg(2+) block is crucial to the roles of NMDARs in ...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1989
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.1989.tb16872.x